Endocrine Abstracts

Introduction: Insulinoma is a rare tumor that causes spontaneous fasting hypoglycemia in a supposedly healthy adult. Mostly these tumors are single and benign, few are malignant and a minority is represented by multiple adenomas. The treatment of choice is surgical removal of the insulinoma, which cures the condition in the majority of cases. However, after performing the surgery, less than 10% of patients either develop diabetes mellitus or continue to have persistent hypogly...

3-iodothyronamine (T1AM) is rapidly catabolized to iodothyroacetic acid after few hours by serum proteins. To avoid a rapid metabolism during any treatment, DMEM devoid of FBS has been used, inducing changes in the cell culture environmental. We evaluated the uptake and the metabolism of different concentrations of T1AM, in presence of supplemented medium, and the presence of 3-iodothyroacetic aldehyde (Ald), a putative intermediate of T1AM catabolism to TA1.<p ...

Introduction: Conventional systemic therapies have limited role in metastasized neuroendocrine tumors (NET). Therefore an increasing role is attributed to 177Lu labeled somatostatin analogues (SA).Case: Man, 52 years, referred because of NET, diagnosed following liver biopsy for hepatic nodules (liver tissue infiltrated by NET, compatible with metastases). Endoscopic ultrasound revealed pancreatic nodular formation, 40×24 mm; 99</sup...

Objective: It has been difficult to identify factors that affect the risk of cancer but we know that people are at higher risk as they get older, or have a strong family history of cancer. The potential influence of environmental and behavioral factors remains poorly understood.Aim: To study associations between PA and family history of malignancy in first-degree and second-degree relatives. As separate analysis, to study associations between PA patients...

Introduction: There is a long delay between the onset of symptoms and correct diagnosis of acromegaly. This study aimed to explore the potential of hand size as a screening tool of acromegaly. Here we present first results of a new screening project.Method: We measured scan-copies of acromegalics (n=27, 9 women, age 18–84 years) and controls (n=111, 71 women, age 19–81 years) and analyzed surface areas of palm and thenar and m...

Introduction: Recently, major advances have been made in genetics of familial acromegaly and isolated pituitary adenoma (FIPA). Mutations in the aryl hydrocarbon interacting protein (AIP) gene have been found in 25–50% of patients with FIPA and familial acromegaly.Aim of the study: Our goal was to identify and collect data on patients who met the criteria for FIPA.Patients and methods: The patients were identified between 2008...

Introduction: The assessment of pituitary function is often achieved by means of sequential determinations (pool) of hormone levels such as prolactin and gonadotrophins. For the determination of prolactin levels the guidelines of the Endocrine Society are clear in recommending a single sample determination.Objective: To evaluate differences between single sample and pool (0′, 20′ and 60′) determinations for assessing prolactin, FSH and ...

Introduction: Amenorrhoea and galactorrhoea are manifestations that may allow earlier diagnosis of pituitary tumors associated with excess somatotropin (ST) and prolactin (PRL) levels.Objective: To evaluate clinical, analytical and imaging characteristics of ST and PRL producing tumors and its affect on diagnosis.Methods: Retrospective study including acromegalic patients diagnosed between 1982 and 2012. Information on clinical, an...

Introduction: Generously supported by IPSEN)-->Elevated levels of somatotropin (ST) and IGF1 in acromegalic patients are associated with high morbidity and mortality. The normalization of ST and IGF1 allows the reversal of most of their negative effects.Objective: To evaluate characteristics present at diagnosis, predictive of cure, after surgery, in patients with ST-producing tumors.Meth...

Introduction: Generously supported by IPSEN)-->Treatment with recombinant ST is subject to strict criteria. Differences in the response to therapy based on the maximum level of ST in diagnostic tests (ST ≤5 vs ST >5 ng/ml), could predict whose patients would benefit more from therapy.Purpase: Assess differences in the response to therapy with rST in patients with IDGH.Methods: S...